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  尤青

  助理研究员。2019年博士毕业于中国科学院分子细胞科学卓越创新中心，随后在beat365在线唯一官网登录从事博士后研究。2025年7月入职beat365在线唯一官网登录。主要关注抗肿瘤药物导致的副作用，致力于开发在不影响抗肿瘤药物治疗效果的前提下能够防治副作用发生的辅助用药。近年来发表SCI论文数篇，参与多项国自然基金项目。

2019-2022，beat365在线唯一官网登录，博士后

2022-2025，上海岸阔医药科技有限公司，助理总监

2025-今，beat365在线唯一官网登录，助理研究员

抗肿瘤治疗药物的副作用发生机制及防治手段

1. You, Q. ^#, Chen, L.^#, et al. (2024). Topical JAK inhibition ameliorates EGFR inhibitor–induced rash in rodents and humans. Science Translational Medicine 16, eabq7074.

2. Chen, L.^#, You, Q. ^#, et al. (2022). Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy. eLife 11, e72443.

3. Sheng, X.^#, You, Q.^#, Zhu, H. ^#, et al. (2020). Enterohemorrhagic E. coli effector NleL disrupts host NF-κB signaling by targeting multiple host proteins. Journal of Molecular Cell Biology 12, 318-321.

4. Sheng, X.^#, You, Q.^#, et al. (2017). Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLoS Pathogens 13, e1006534.

5. Liu, S., Zeng W., Li, W., You, Q., et al. (2023). OQL025, a topical cream for the prevention of epidermal growth factor receptor inhibitor-induced skin rash. Cancer Research 83, 3211.

6. Wu, C., Fang, K., Zeng W., Li, W., Liu, S., You, Q., et al. (2023). OQL06x, a gut-restricted janus kinase inhibitor to control epidermal growth factor receptor inhibitor-induced diarrhea. Cancer Research 83, 3212.

7. Chen, L., You, Q., et al. (2021). GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib. Acta Pharmacologica Sinica 43, 1534-1543.

8. Liu, Z. ^#, Li, H. ^#, Hong, C., Chen, M., Yue, T., Chen, C., Wang, Z., You, Q., et al. (2018). ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death. Frontiers in Immunology 9, 2647.

9. Peng, H. ^#, Yang, J. ^#, Li, G., You, Q., et al. (2017). Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Research 27, 657-674.